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June 2015

Volume 2  Issue 2
Research Article

High Rates of Hepatitis B and C Viral Infections in Asymptomatic Pregnant Women and Females of Reproductive Age in Ilesa and Ibadan, Southwestern Nigeria

Taofeeq Ayodeji Awogun, Mercy Ebere Okoroji, Oluwadabira Ayodeji Taiwo, Abisola Odunayo Adegoke, Tobi Olumide Obijimi, Ayooluwa Busayo Ajetomobi, Samie Adenike Adekunle, Waidi Folorunso Sule*

Clearly, HBeAg-positive mothers are infected with HBV and about 70-90% of such mothers, when pregnant, can vertically infect (i.e. infectious mothers) their non-immune newborns peri-partum; 90% of such infants are likely to develop chronic HB/hepatocellular carcinoma. We aimed to detect evidence of HB and C viral infections/infectiousness in archived sera ofasymptomatic pregnant women from Ilesa (PWIL, n=27) and Ibadan (PWIB, n=25) and females of reproductive age from Ilesa (FRAIL, n=40), and determine associated participants’ variables. Sera collected in Wesley Guild Hospital, Ilesa, Osun State and Jericho Nursing Home, Ibadan, Oyo State, Nigeria were screened with commercial ELISA kits for HBsAg, HBeAg and HCV antibody, and results obtained were analyzed with t-test, ANOVA and binary logistic regression.                                                                                                                                                                                                                              Full textDownload PDF 

Research Article

Alcohol Abuse and Hepatocellular Carcinoma: Epidemiology

Michael C. Kew *

Consumption of alcohol continues to increase in a number of countries, and is now among the most disabling habits contributing to the global burden of disease. Drinking alcohol in these amounts is linked to financial status in terms of gross domestic product, occurring most often in poor or relatively poor people and those marginalized from society. Men generallyconsume more alcohol than do women, have higher death rates, and die at a younger age. The proportion of alcohol-attributable deaths has increased in recent years, mainly attributable to increasing numbers of women drinking to excess. Heavyalcohol consumption is currently associated with a more than 5-fold increased cumulative probability of death, as well as adecreased mean age at the time of death. 

                                                                                                                                                                      Full textDownload PDF

Research Article

In-vitro Gas Production of Different Dietary Fibre Sources Incubated with Faecal Microflora to Test Applicability of Preventing DIOS in Patients Suffering from Pancreatic Exocrine Insufficiency – Studies in Minipigs Used as A Model for Humans

Anne Mößeler*, Sandra Vagt, Martin Beyerbach, Josef Kamphues

Patients suffering from cystic fibrosis (CF) often suffer from an exocrine pancreatic insufficiency (PEI) and have an increased risk for distal intestinal obstruction syndrome (DIOS). To ensure a high energy density in the diet to prevent malnutrition and meteorism in these patients the dietary fibre supply is low which might exacerbate constipation and DIOS. The aim of this study was to test the in-vitro gas production of different fibre concentrates incubated with porcine faecal microflora.

                                                                                                                                                                                                                             Full textDownload PDF


Research Article

Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Portal Hypertension in Mexican Population: Clinical Outcomes and Survival

José Alejandro Velasco-Zamora, Everardo Muñoz-Anaya, Karel Melchor-Mendoza, Elisa Gómez-Reyes, Adrián González-Aguirre, Iván Casanova-Sánchez, Lourdes Ávila-Escobedo, Graciela Elia Castro-Narro, Eric López- Méndez*

Nowadays portal hypertension due to cirrhosis is an important reason of consultation for gastroenterologist around the world. The complications of portal hypertension are variceal hemorrhage, refractory ascites and hydrothorax. These are main causes of death in this group of patients. Although portal hypertension can be present in the absence of cirrhosis. In both of this entities (cirrhotic and nor-cirrhotic portal hypertension) the aim of the treatment is to diminish portal pressure and by consequence minimize the severity of the complications.
                                                                                                                                                                      Full textDownload PDF


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