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September 2016

Volume 3  Issue 3
Research Article

Role of p38 Signaling Pathway in Pentagastrin-Regulated Growth of Colorectal Carcinoma

Jia-Ding Mao*, Pei Wu, Jian Wu, Liang Tao, Ping Wu, Guang Yang, Wen-Wen Guo, Jun Wang

Colorectal carcinoma (CRC) is one of the most common malignant tumors of the human digestive tract and is the second to the third leading cause of gastrointestinal cancerrelated mortality worldwide. In developed countries such as Australia, North America, New Zealand and parts of Europe, CRC is considered to be a disease of Western lifestyle and has an incidence of 35-50/10 million people/year. In China, the incidence and mortality of colon cancer now rank third and fifth, respectively.

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Research article

Non-Operative Management of Patients with Acute Cholecystitis Including Percutaneous Trans-Gallbladder Aspiration

Shun-ichi Misawa*, Hiroto Sakamoto, Akira Kurogochi, Yasushi Kirii, Hiroyuki Takagi, Alan Kawarai Lefor, Masanobu Hyodo

Early cholecystectomy is generally recommended in patients with acute cholecystitis (AC). The Tokyo guidelines published in 2007 provide recommendations for management depending on the severity of AC. Updated 2013 guidelines suggest that early laparoscopic cholecystectomy is mandatory for patients with mild AC, while delayed laparoscopic cholecystectomy can be performed in patients with moderate or severe AC after drainage and / or supportive care.

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